Title: Process for producing 5-fluoropyridine derivatives
Application Number: 92106681 Application Date: 1992.08.21
Publication Number: 1083050 Publication Date: 1994.03.02
Approval Pub. Date: Granted Pub. Date:
International Classifi-cation: C07D213/69
Applicant(s) Name: Xinhua Pharmaceutical Factory, Shandong Address: 255005
Inventor(s) Name: Yang Wenheng
Attorney & Agent: CAI SHAOQIANG
Abstract:
     Process to prepare 5-fluoropyridine derivatives is that correspondent fluoro-acetate is condensated with formate by use of sodium alkoxide as condensating agent and then cyclized with butanoneamide by use of sodium alkoxide as cyclizing agent to prepare 2,6-dihydroxy-5-fluoro-3-acetylpyridine. Use of the 3-acetyl-can synthesize corresponding alkyl 5-fluoronicotinoyl-acetate, or 5-fluoronicotinic acid derivatives after oxidation, which may be used to synthesize alkyl 5-fluoronicotinoyl-acetate.
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