Title: Process for preparing N-(tetrahydrofuran-2-formyl) piperazine
Application Number: 92110026 Application Date: 1992.08.26
Publication Number: 1070188 Publication Date: 1993.03.24
Approval Pub. Date: Granted Pub. Date: 1996.08.14
International Classifi-cation: C07D241/06,C07D307/24
Applicant(s) Name: Hebei Medicine Inst. Address: 050061
Inventor(s) Name: Liu Yuting
Attorney & Agent: ZHANG ERQUN
Abstract:
     N-(tetrahydrofuran-2-formyl) piperazine that is a key intermediate during preparing an antihypertension medicine is prepared by reaction of tetrahydrofuryl-2-formyl chloride with piperazine and/or with piperazine salt, or with N-protected piperazine and then removing protecting radical. The said product does not contain N-(furyl-2-formyl) piperazine, so purity is higher and cost is low.
Time: 4