Title: Enantioselective synthesis of 5,6-dihydro-(S)-4-(ethylamino)-(S)-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide and related compounds
Application Number: 94191502 Application Date: 1994.03.16
Publication Number: 1119866 Publication Date: 1996.04.03
Approval Pub. Date: 1999.11.24 Granted Pub. Date: 1999.11.24
International Classifi-cation: C07D495/04
Applicant(s) Name: Merck Address:
Inventor(s) Name: Paul Sohar;David J. Mathre;Thomas J. Blacklock
Attorney & Agent: ZHANG YUANZHONG
Abstract:
    A key step in the synthesis of 5,6-dihydro-(S)-4-(ethylamino)-(S)-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide and related compounds is a Ritter reaction with an unexpected tendency to proceed with retention of chirality.
Time: 5