Title: Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
Application Number: 94192117 Application Date: 1994.03.24
Publication Number: 1123547 Publication Date: 1996.05.29
Approval Pub. Date: 2001.06.27 Granted Pub. Date: 2001.06.27
International Classifi-cation: A61K31/335;A61K31/34;A61K31/35;A61K31/38;A61K31/40;A61K31/44;A61K31/445;A61K31/535;C07D203/04;C07D20
Applicant(s) Name: The Research Foundation of The State University of Address:
Inventor(s) Name: Iwao Ojima (US) Ezio Bombardelli
Attorney & Agent: TIAN MINGSHENG JIANG JIANCHENG
Abstract:
    The present invention is directed to novel taxanes useful as chemotherapeutic agents or their precursors. Processes for preparing the novel taxanes include coupling reactions, in the presence of a base, of baccatin of formula (III) or (IV) with formula (V).The invention also provides pharmaceutical compositions including the novel taxanes and method for treatment of certain cancers with these new compounds.
Time: 3