Title: HIV protease inhibitors in pharmaceutical combinations for the treatment of AIDS
Application Number: 94191671 Application Date: 1994.03.24
Publication Number: 1120316 Publication Date: 1996.04.10
Approval Pub. Date: 2002.09.04 Granted Pub. Date: 2002.09.04
International Classifi-cation: A61K31/444;A61K31/7068;A61K31/7072;A61K31/708;A61P31/18;C07D401/06
Applicant(s) Name: Merck Address:
Inventor(s) Name: Joseph P. Vacca;James P. Guare;Bruce D. Dorsey
Attorney & Agent: GUAN LIXIN JIANG JIANCHENG
Abstract:
    Compounds of formula where R1 and R2 are independently hydrogen or optionally-substituted C1-4alkyl or aryl, or R1 and R2 are joined together to form a monocyclic or bicyclic ring system, are HIV protease inhibitors. These compounds are useful in the prevention or treatment of infection by HIV and in the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
Time: 6
<- Previous Patent:Crystalline benzathine salt of ce...   |  Next Patent:Cephalosporin derivative ->