Title: 4-arylisoindole analgesics
Application Number: 94192113 Application Date: 1994.03.28
Publication Number: 1123546 Publication Date: 1996.05.29
Approval Pub. Date: Granted Pub. Date:
International Classifi-cation: A61K31/40;A61K31/44;C07D209/44;C07D401/04;C07D409/04
Applicant(s) Name: Ortho Pharmaceutical Corporation Address:
Inventor(s) Name: Richard J. Carmosin;John R. Carson;Dennis C. Liott
Attorney & Agent: TIANG AIJUN LUO CAIXI
Abstract:
    The 4-arylisoindoles of the formula (I)are effective analgesics including stereoisomers and pharmaceutically acceptable salts thereof, wherein (II) is (III), (IV) or (V); with the proviso that there is 0 or 1 unsaturated bond in the isoindole ring and with the proviso that where the stereoisomer is: a) the 3a beta , 4 beta , 7a alpha diastereomer, then a double bond joins the 5- and 6-position carbons or the 6- and 7-position carbons; b) the 3a beta , 4 alpha , 7a alpha or the 3a beta , 4 alpha , 7a beta diastereomers, then the double bond joins the 5- and 6-position carbons; and c) the 3a beta , 4 beta , 7a beta diastereomer, then the double bond joins the 6- and 7-position carbons.
Time: 8