Title: Novel amino acid derivatives with improved multi-drug resistance activity
Application Number: 95196279 Application Date: 1995.11.13
Publication Number: 1163605 Publication Date: 1997.10.29
Approval Pub. Date: 2003.01.22 Granted Pub. Date: 2003.01.22
International Classifi-cation: A61K31/16;A61K31/395;C07C237/02;C07D213/81;C07D233/90
Applicant(s) Name: Vertex Pharmaceutical Incorporated Address:
Inventor(s) Name: R. E Zeller;M. W. Harding
Attorney & Agent: TANG WEIJIE
Abstract:
    The present invention relates to compounds that can meintain, increase, or restore sensitivity of cells to therapeutic or prophylactic agents. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well-suited for treatment of multi-drug resistant cells, for prevention of the development of multi-drug resistance, and for use in multi-drug resistant cancer therapy.
Time: 4
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