Title: Improved process for alkylation with triazoles
Application Number: 95119257 Application Date: 1995.11.14
Publication Number: 1133838 Publication Date: 1996.10.22
Approval Pub. Date: Granted Pub. Date:
International Classifi-cation: C07C255/35;C07D249/08
Applicant(s) Name: Rohm and Haas Co. Address:
Inventor(s) Name: Deborah Diane Graves
Attorney & Agent: DU JINGYING
Abstract:
    The present invention provides an preparation process of compound of the formula I: wherein Z is optionally substituted (C6-C10)aryl group; R is a hydrogen atom, a (C1-C12)alkyl group, a (C3-C8) cycloalkyl group, a (C2-C8)alkenyl group, a (C5-C8) cycloalkenyl group, a (C2 to C8)alkenyl group, an optionally substituted (C7 to C14)aralkyl group, a (C2 to C4)alkynoxy group, an optionally substituted (C6 to C10)aryloxy group or a hydroxy group; Q is an optionally substituted 1-(1,2,4-triazolyl) or 4-(1,2,4-triazolyl); X is hydrogen or CN; m is zero or one; n is one or two; which process comprises the reaction of the formula (ii) : wherein Z, R, X, m and n are the same as defined above, and T is selected from halo, tosyl and mesyl with a triazole salt, and wherein the triazole salt is added to the compound in multiple additions or continuously.
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