Title: Prepn of polyhydric alcohol amine
Application Number: 95112778 Application Date: 1995.11.20
Publication Number: 1132739 Publication Date: 1996.10.08
Approval Pub. Date: Granted Pub. Date: 2000.07.26
International Classifi-cation: C07C213/04,C07C215/10,C07C215/12
Applicant(s) Name: Jiangsu Prov. Inst. of Atomic Medicine Address: 214063
Inventor(s) Name: Luo Shineng, Xie Minhao
Attorney & Agent: SHI XUDAN SUN ZIMEI
Abstract:
     A process for preparing polyhydric alcohol amine as non-ionic X-CT contrast agent including such products as 3-amino-1,2-propanediol used to prepare iohexol, N-methyl-2,3-dihydroxypropylamine used to prepare ultravist, and N,N-bi 2,3-dihydroxypropyl]amine includes reaction of chloropropanediol with relative aqueous solution of RNH2, neutralization, filtering and distillation, and features shorter reaction period and high safety.
Time: 5