Title: Process for preparation of aromatic 0-sulfocarboxylic acids and sulfonylureas
Application Number: 95196982 Application Date: 1995.12.11
Publication Number: 1171101 Publication Date: 1998.01.21
Approval Pub. Date: Granted Pub. Date:
International Classifi-cation: C07C303/22;C07D521/00
Applicant(s) Name: Novartis AG Address:
Inventor(s) Name: U. Sigerist;M. Maler;J. brunisholz
Attorney & Agent: GUAN LIXIN
Abstract:
    The invention relates to a process for the preparation of ortho-sulfocarboxylic acids, which comprises: a) in a first reaction step, diazotising an aromatic ortho-aminosulfonic acid in the presence of an acid and nitrite in water, in an organic solvent or in a mixture thereof, to an ortho-diazonium sulfonate, and, b) in a second reaction step, reacting the ortho-diazonium sulfonate in the presence of a palladium catalyst in water, in an organic solvent or in a mixture thereof, with carbon monoxide, under overpressure, to an aromatic ortho-sulfocarboxylic acid. The invention also relates to a process for the preparation of sulfonylureas using ortho-sulfocarboxylic acids as intermediates.
Time: 8