Title: (8S,18S)-1,4,10,13,16-pentazatricyclo [16.3.0.0 4.8] heneicosane-9,17-diketone and its prepn process
Application Number: 02139147 Application Date: 2002.10.09
Publication Number: 1403458 Publication Date: 2003.03.19
Approval Pub. Date: Granted Pub. Date: 2004.08.04
International Classifi-cation: C07B57/00,C07D487/14
Applicant(s) Name: Wuhan Univ. Address: 430072
Inventor(s) Name: Yang Xuemei, Fe Enqin
Attorney & Agent: cheng xiang feng weibeng
Abstract:
     The present invention discloses one kind of C2 symmetrical amide type chiral macrocyclic polyamine (8S, 18S)-1,4,10,13,16-pentazatricyclo [16.3.0.0.4.8] heneicosane 9-17-diketone and its preparation process. The L-proline as material is esterified, bridged and cycle capped to prepare the chiral compound (8S, 18S)-1,4,10,13,16-pentazatricyclo [16.3.0.04.8] heneicosane 9,17-diketone. The said preparation process needs no protection with functional radical, no high dilution, no chromatographic column purification and no special reagent and apparatus and is simple, convenient and low in cost. The said compound may be used in the separation and analysis.
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