Title: Spliting method for DL-pantoyl internal ester
Application Number: 02137589 Application Date: 2002.10.23
Publication Number: 1491948 Publication Date: 2004.04.28
Approval Pub. Date: Granted Pub. Date: 2005.05.04
International Classifi-cation: C07D307/56,C07B57/00
Applicant(s) Name: Xinhecheng Co., Ltd., Zhejiang Prov. Address: 312500
Inventor(s) Name: Wu Zaihong
Attorney & Agent: dai xiaoxiang
Abstract:
     The present invention relates to one splitting method for DL-pantoyl internal ester. Splitting agent of the present invention is organic base R-NH2, where R is C15H15. The splitting process includes the following steps: reacting purified splitting agent with acid, dissolving in water while heating, dropping digest of DL-pantoyl internal ester, with the molar ratio between the splitting agent and DL-pantoyl internal ester being 0.5-0.7; suction filtering the reacted liquid, racemizing the filter cake, recovering the splitting agent; adding organic solvent to the filtrate for azeotropic dewatering, evaporating to eliminate excessive organic solvent and crystallization. The present invention has splitting agent with high selectivity to DL-pantoyl internal ester, high total utilization of DL-pantoyl internal ester, high splitting yield, reusing of the splitting agent and low DL-pantoyl internal ester producing cost.
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