Title: Process for producing azetidinone compounds
Application Number: 03801808 Application Date: 2003.02.17
Publication Number: 1610663 Publication Date: 2005.04.27
Approval Pub. Date: 2006.10.04 Granted Pub. Date: 2006.10.04
International Classifi-cation: C07D205/08,C07F7/18,B01J27/125,B01J27/135,B01J31/12,C07B61/00
Applicant(s) Name: Takasago Perfumery Co., Ltd. Address:
Inventor(s) Name: Matsumoto Takaji, Murayama Toshiyuki
Attorney & Agent: fan weimin yang jing
Abstract:
     It is intended to provide a process for selectively obtaining an intermediate in synthesizing a desired carbapenem-type antibacterial agent having a methyl group at the 1'-beta-position in a short period and at a high yield under mild conditions while overcoming problems occurring in the existing method. Namely, a process for producing an azetidinone compound having a 1'-beta configuration characterized in that a reaction represented by the following formula is carried out in the presence of a specific metal compound and a base: wherein R<1> represents hydrogen or a hydroxy-protective group; L represents a leaving group; R<2> represents hydrogen or lower alkyl; R<3> represents alkyl, aralkyl, etc.; and X represents oxygen or sulfur.
Time: 10
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