Title: Altered antibodies having improved antigen-binding affinity
Application Number: 200480028040 Application Date: 2004.07.26
Publication Number: 1894695 Publication Date: 2007.01.10
Approval Pub. Date: Granted Pub. Date:
International Classifi-cation: G06F19/00;G06G7/60;C07K16/00;A61K39/395
Applicant(s) Name: Biogen Idec Ma Inc. Address:
Inventor(s) Name: Van Vlijmen Herman;Sherman Brian Woody H.;Lugovsko
Attorney & Agent: wu xiaonan bian xinqin
Abstract:
    The invention relates to methods of modulating the antigen-binding affinity of an antibody by determining, using data corresponding to the structure of a complex between the antibody and an antigen in a solvent, a representation of a charge distribution of the CDRs of the antibody which minimizes electrostatic contribution to binding free energy between the antibody and the antigen in a solvent. Guided by these determinations, the antibody is accordingly modified (altered) to improve upon, e.g., antibody/antigen binding by modifying at least one amino acid residue to decrease the binding free energy between the antibody and antigen when bound in a solvent.
Time: 7
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