Match Application Number Document Title
1 99814244 Reversible aqueous pH Sensitive lipidizing reagents, compositions and methods o...
The present invention provides lipidized conjugates comprising an amino group-containing biologically active substance and a lipophilic group capable of penetrating a biological membrane....
2 01822470 Transfer hydrogenation process and catalyst
A catalytic transfer hydrogenation process is provided. The catalyst employed in the process is a metal hydrocarbyl complex which is coordinated to defined bidentate ligands substituted ...
3 85102578 Method for producing high purity insulin
The technology of this invention is characterised by using industrial crude insulin as raw material, purification effected by series chromatography using alkali Al2O3 (or CM-Sephadex C-5...
4 02824888 Method for the preparation of escitalopram
The invention relates to a method for the preparation of escitalopram by cyanation of optically active intermediates of the formulas III and II below, and the preparation of such interme...
5 85103901 Method for recovery of starch and protein from rhizome
The present invention provides a simple method for recovery of almost pure white starch and protein of higher commercial value by a way which prevents mincing the sludge or discoloring t...
6 85102340 Process for the preparation of acyltripeptide immunosttimulants
Acyltripeptides having the formula below, pharmaceutically acceptable salts thereof and intermediates therefor; processes for their preparation and use as immunostimulant and antibacteri...
7 85101907 Production of single segment dominent human r-interferon
In the presence of sulfide reducing agent and protein denaturant, after gel filtration raw human r-interferon, can be efficiently made into single segment dominant human r-interferon.
8 85101554 Process for the production of highly solubilized protein
A human gamma-type aqueous solution with a hign concentration is obtained, by removing a protein denaturation agent from a dilute aqueous solution of human gamma-type interferon containin...
9 85105258 Process for synthesising enalapril
Enalapril is a newly developed blood vessel tension swivelase inhibitor. Its carative effect for various type of hypertensions is notable in clinic and it is also used for curing congest...
10 85104164 Process for preparing covalent conjunct agent of bacterial polysaccharide and i...
By using the double genus interval group having covalent conjunct preperty and having the advantage of purification of conjunct agent, polysaccharide is conjoined with immunogen bacteria...
11 85104021 Chitin-protein complex with nematocidal activity
Chitin-protein complex is made from chitin containing bio-waste of class crustacean. This complex is different from chitin and deacetylate chitin, and having the activity of interfering ...
12 85107875 Mutual separation of proteins
A method of separating a protein from another protein having a methionine residue at its amino terminal, which is characterized by subjecting a mixture of the above proteins to a separati...
13 85107088 Preparation of peptide-substituted heterocyclic immunostimulants
The invention is directed to a method for preparation of peptide-substituted heterocyclic compounds having the formula below, pharmaceutically acceptable salts thereof and intermediates t...
14 85106564 Process for preparing polypeptide related to alpha-human afrial natriuretic pol...
A polypeptide of the general formula R-Asn-Ser-Phe-Arg-Tyr-OH can be used for development of a agent for clinical diagnosis of primary hypertension and used to study its pathophysiology....
15 85105655 Process for the preparation of novel 1-methy1-4, 5-dihydroorotic acid derivativ...
There are disclosed 1-Methyl-4, 5-dihydroorotyl-histidyl-prolinamide or a pharmaceutically acceptable acid addition salt thereof, processes for their preparation and pharmaceutical compo...
16 85105429 Method for preparing carboxylic acid ester derivatives of deglucoteicoplanin
The present invention concerns a method for preparing carboxylic acid ester derivatives of deglucoteicopanin i.e. carboxylic ester derivative of glucoside part of antibiotic teicoplanin....
17 85109243 Process for the preparation of antihypertensive octahydro-6-azaindole dipeptide...
Octahydro-6-azaindole dipeptide derivatives are inhibitors of angiotensin converting enzyme, useful for the treatment of hypertension and have the formula: wherein R1, R2, R3,and R4 are d...
18 85109722 Process for preparing dynophine derivative
A novel polypeptide is made of 7-10 amino acids, it maybe the same as ramification of Dynorphine.The novel polypeptide which is useful as an analgesic.
19 85107448 Manufacturing method for protein-protective antigen determinant group of cross-...
A peptide of amino-acid sequence contains a non-repeat antigen determinant group of cyclo-periplasm spore which is a member of the genus of malarial parasite. The peptide is able to indu...
20 86101066 Process for the production of new trifluoromethyl Ketone Substituted peptide de...
The invention concerns pharmaceutically useful trifluoromethyl ketone substituted di-, tri- and tetra-peptide derivatives of the formulae Ia, Ib, Ic set out here:W after, and salts thereo...
21 86100747 Process and reagent for the specific determination of pancreatic alfa-amylase
The present invention provides a process for the specific determination of pancreatic alpha-amylase in the presence of salivary alpha-amylase in body fluids, especially in serum plasma, d...
22 85109736 Mfr. method and the composition of new peptide-aldehyde compound
The invention relates to new peptide-aldehydes and a process for the preparation thereof, furthermore to pharmaceutical compositions containing the same. According to a feature of the pre...
23 86101798 Process for the extraction and purification of proteins from culture media prod...
The process is applicable to the supernatant of engineered yeast cells disrupted in the presence of a non-ionic detergent: it comprises the precipitation of contaminants by polyethylene g...
24 86101489 Process for preparation of novel insulin peptides and novel injectable solution...
Insulin derivatives having a charge which is positive compared with the charge of human insulin at neutral pH, can be used to prepare solutions having prolonged insulin action. In the nov...
25 86100915 Method of somatotropin solubilization and naturation
A method for solubilization and naturation of somatotropin protein from refractile bodies of host cells is disclosed. The method embraces the discovery that an aqueous urea or dimethylsul...
26 86101268 Process for the preparation of novel peptidase inhibitors
This invention relates to analogs of peptidase substrates in which the amide group containing the scissile amide bond of the substrate peptide has been replaced by an activated electrophi...
27 86102644 Expression of factor seventh and ninth activities in mammalian cells
Methods are disclosed for producing proteins having biological activity for blood coagulation mediated by Factor VIIA or Factor IX. The proteins are produced by mammalian host cells which...
28 86102889 Improved method for man-promoting growth factor C
A process for selecting DNA sequences that are optimal for the production of polypeptides in hosts transformed with those DNA sequences. These DNA sequences, which code for a variety of h...
29 86102858 Recombinant surface antigens of swine mycoplasma and vaccines and diagnostics b...
Surface antigens of swine mycoplasma, such antigens prepared by recombinant DNA methods, a swine mycoplasma vaccine, based on such antigens, methods of treating swine to prevent enzootic ...
30 86101850 Process for the preparation of N,N
NG ,NG
31 86104077 Process for purifying human physiologically active polypeptide
An aqueous solution containing a physiologically active polypeptide, which is produced by recombinant DNA technique and which has cytotoxic activity against L-M cells and is capable of i...
32 86103254 Process for the preparation of adducts of dipeptide and amine
The dipeptide composed of an N-protected L-aspartic acid and L- phenylalanine methyl ester forms with amines sparingly soluble addition compounds which can easily be removed from the reac...
33 86103330 Process for the preparation of novel glycopeptide derivatives
Novel glycopeptide antibiotics can be prepared from the glycopeptide antibiotics vancomycin, A51568A, A51568B, M43A and M43D by reaction with a ketone or aldehyde followed, if appropriate...
34 86102829 Purification method for antihemophilic factor
The present invention provides a purification method for protein. This method can make protein purificatory by use of column chromatography in the presence of hydration additive selected...
35 86103730 Removal of the N-terminal methionine from methionylproteins
The N-terminal methionine in the methionylprotein can be efficiently removed by reacting methionylprotein with aminopeptidase.
36 86103718 Synthetic vaccines for foot and mounth disease
Compounds having activity in treating or preventing foot and mouth disease are disclosed. The compounds contain a sequence of the formula X-A-Y-B-Z in which A and B are amino acid residue...
37 86103598 Process for preparing water soluble xanthylium derivative substrates and uses t...
Water soluble xanthylium derivative substrates of rhodamine 110 and rhodol permit spectrophotometric and fluorescent measurements of trypsin-like enzymes without the addition of organic s...
38 86103528 Method for selectively increasing the ratio of single major components of teico...
The object of this invention is to provide a method for selectively increasing the ratio of the single T-A2 major components in the T-A2 complex. More particularly, the object of this inv...
39 86104774 Method for preparing of lean mycin derivative
Distamycin A derivatives of formula (I) is disclosed in this invention, wherein R is a single replace or double replace amido, and each group R1 is, independently, hydrogen oralkyl. Accor...
40 86101511 Method for the extraction of chrysalis stinkingless protein with organic solvent
The dry or wet chrysalides of Chinese silkworm, tussah or castor plant silkworm containing rich protein are shelled and put into water loving organic solvent with low boilling point to p...
41 86104458 Purification of hemoglobin and modified hemoglobin by affinity chromatography
The present invention relates to a method for the purification of hemoglobin by the technique of affinity chromatography. Contrary to current belief, the binding of oxygen and selected po...
42 86105139 Method to produce low-inositol hexphosphate soybean separated protein
A high quality soy protein isolate with significantly reduced aluminum content and substantially free of phytic acid and phytate complexes is prepared by aqueous extraction of defatted pa...
43 86106574 Human insulin analogues
Novel rapid-acting human insulin analogues are provided having less tendency to self-association into dimers, tetramers, hexamers, or polymers. The novel human insulin analogues are forme...
44 86105870 Blood vessel tension peptide protoenzyme inhibitor with 5-amino-2.5-disubstitut...
A series of novel polypeptide derivatives, containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues, which are useful for inhibiting the angiotensinogen-cleaving action of th...
45 86107569 Selective chemical removal of protein amino-terminal residue
The invention relates to a process for producing a compound having an amino acid sequence defining a biologically active peptide or protein from a compound of the formula H-X-Pro-Peptide ...
46 86107142 Extraction of silk fibroin powder from broken silkworm cocoon
The present invention discloses a method of extracting silk fibroin powder from broken silkworm cocoon as raw material which is first impregnated with hydrogen peroxide solution to extra...
47 86106046 Amides of teicoplanin compounds
The present invention relates to amide derivatives of teicoplanin compounds. Teicoplanin is an antibiotic substance active mainly against gram-positive bacteria and its derivatives, which...
48 86106023 New support for solid phase synthesis of peptide
A new kind of inorganic support is invented for the solid phase synthesis of peptide. This support is successfully prepared by four steps of synthesis using trialkyl butoxy carbonyl glyc...
49 86107666 Hybridoma cell lines and their monoclonal antibodies to human pluripotent granu...
Murine-derived hybridoma tumor cell lines and monoclonal anti-human pluripotent Granulocyte Colony Stimulating Factor antibody substances produced by these cell lines. Use of said monoclo...
50 86107931 Peptide containing immunoexcitant
The present invention relates to peptide components of formula 1, pharmaceutically acceptable base salts thereof, pharmaceutical compositions and their use as antiinfective agents where R...
51 86108593 Snake venom growth arresting peptide
Novel cytotoxic agents are provided as small polypeptides related to a low molecular weight peptide derived from Crotalus atrox. The compounds may be used by themselves or in combination ...
52 87100085 Method for purifying disproportionation enzyme for hyperoxide
This invention is a method for purifying superoxide disproportionated enzyme, in which an unfreezing technique is used to rupture the membrane of erythrocyte for increasing the yield of ...
53 86108977 N-amide glucuromide glycoside antibiotic A40926 group and glycoside antibiotic ...
The present invention concerns new antibiotic substances denominated antibiotic A 40926 N-acylaminoglucuronyl aglycon complex AB, antibiotic A 40926 N-acylaminoglucuronyl aglycon factor A...
54 86104131 L-asparaginyl aminodipeptide sweetening agent and its production
This invention refers to a L-asparaginyl aminodipeptide sweetening agent and its production. The raw materials, such as D-alanine, glycine, L-asparagic acid are all acceptable by human b...
55 87101721 Novel bradykinin antagonist and application
The activator bradykinin can be changed into bradykinin antagonist when aromatic acid or similitude of D-type armatic acid is substituted for peptide hormone bradykinin or seventh priori...
56 87100465 Method for producing hepatitis B virus proteins in yeast
The entire hepatitits B virus pre-S antigen gene linked in one contiguous reading frame to the hepatitis B virus surface antigen gene has been expressed in Saccharomyces cerevisiae. The e...
57 87100308 Polypetide compounds
New compounds which have potent V2-vasopressin antagonistic activity are prepared by a 1,6-cyclization using peptide bond formation. The structures of the compounds are characterized by a...
58 87102744 Composition for stimulating chondrocytes and osteoblasts, method for its produc...
A composition for stimulating chondrocytes and osteoblasts, a method for producing it from bones from fetal to approximately twelve month old mammals, and pharmaceutical products for the ...
59 87102497 Alpha interferon analogue
A novel alpha interferon analogue, lacking a diaminopeptidase site at positions 22-23, may be expressed intact in hosts whose primary proteolytic activity against the natural species is a...
60 87102304 Compounds for anti-dementia medicine and its usage
The invention relates to novel compounds having a nootropic activity, the use of ACE inhibitors as medicaments having nootropic activity, agents containing them, and their use in the trea...
61 87101862 Polypeptide, DNA and its use
A human basic fibroblast growth factor (hbFGF), which is usable for a cure promoter for burns etc., therapeutic agent for thrombosis etc. or a reagent for promoting cell cultivation, can ...
62 87104447 Method of chain combination
Production of human relaxin or novel human relaxin analogs by combination of a human relaxin A-chain and B-chain comprises combining the reduced form of the human relaxin A-chain and the ...
63 87104279 Method of preparing toxoid
A method of preparing toxoid by treating a toxin with an oxidizing agent is described. Preparation of a vaccine against pertussis in accordance with the method is illustrated.
64 87104430 Immunoglobulin conjugates
Immunoglobulin conjugates formed by reaction of an antineoplastic indole-dihydroindole vinca alkaloid containing a hydrazine group attached at C-3 or C-4 with an oxidized glycoprotein con...
65 87103568 HTLV-3/LAV virus related peptides, antibodies to the peptides, vaccines, passiv...
Vaccines effective in the inhibition of infection caused by the family of retroviruses, HTLV-III, Human T-cell Leukemia Virus, LAV, Lymphadenopathy-associated virus, ARV-2, AIDS-Related V...
66 87106307 L-aminodicarboxylic acid esters
Sweeteners of the formula: and food-acceptable salts thereof, where the substituents are disclosed herein.
67 87105478 Neuronotrophic factor
A novel neuronotrophic factor having a molecular weight of about l4,400 daltons and an isoelectric point of about l0 is prepared by homogenization of mammalian brain tissue, particularly ...
68 87104988 Novel peptides
The invention relates to novel insulin compound and novel injectable solutions having prolonged insulin action.
69 87104963 Stable pharmaceutical preparation containing granulocyte colony stimulating fac...
A stable granulocyte colony stimulating factor-containing pharmaceutical preparation contains, in addition to granulocyte colony stimulating factor as an active agent, at least one substa...
70 87101499 A preparation method of the polypeptide with nor-statine and nor-cyclostatine
Polypeptides and derivatives thereof containing nor-statine and nor-cyclostatine are useful for inhibiting the angiotensinogen-cleaving action of the enzyme renin.
71 87107019 Process for transforming human insulin precarsor to human insulin
This specification describes a process for converting a human insulin precursor having the formula: to human insulin, which comprises treating such human insulin precursor with trypsin an...
72 87105898 Process for preparing of absolute stereochemical formula crystallographic compo...
Immunoregulatory N-(S-3-alkylheptanoyl)-D-gamma-glutamyl-glycyl-D-alanine and esters thereof; and an improved process and intermediates of a novel immunoregulatory N-(R-3-4-heptanoyl and ...
73 87106696 Proteins and process for preparing them, ADN sequence, antibodys and their appl...
The present invention relates to the development of a vaccine against schistosomiasis. It relates to a protein which includes the epitopes of the p28 protein, a poxvirus containing a gene...
74 88100378 New peptidase inhibitor
This invention relates to activated electrophilic ketone retroamide analogs of certain peptidase substrates. These compounds are useful in inhibiting serine-, thiol-, carboxylic acid- and...
75 87101164 Process for preparing phosphinic acid derivatives
The invention provides compounds of the formula I wherein R1-R5 and X have the significance given in the description, and their pharmaceutically acceptable salts. They inhibit the enzyme ...
76 87107275 Monoclonal antibody specific to neutrophils
A hybrid cell line capable of producing monoclonal antibodies uniquely specific to human neutrophils. The monoclonal antibody has no reactivity with other human peripheral blood cells and...
77 88101111 Glycopeptide decovery process
A process for recovering vancomycin-type glycopeptide antibiotics which comprises 1) commingling the fermentation medium in which the antibiotic is produced with a polystyrene divinylbenz...
78 88100913 Polypeptide, DNA and its use
A mutein of basic fibroblast growth factors (bFGF) possesses fibroblast growth promoting activity, growth stimulating activity of capillary endothelial cells and angiogenic activity, has ...
79 88100645 Method for recovering somatotropins from dilute aqueous solutions
A method for the recovery of somatotropin, in particular a fragment of somatotropin, from dilute aqueous solutions comprising adding to the aqueous solution a salt of transition metal to ...
80 88100260 Anticoagulant peptides
This invention relates to peptide derivatives which are useful anticoagulant agents.
81 88101653 Sweetener L-aspartyl-3-(bicycloalkyl)-l-alanine alkyl esters
The present invention relates to L-aspartyl-3-(bicycloalkyl)-L-alanine alkyl esters having high sweetness intensity, of the formula I wherein R
82 88101403 Extraction of hemocyanin from polyglycol solution
The present invention provides an extraction method of hemocyanin from polyglycol solution. It uses simple instruments and equipments with simple operation and high yield.
83 88102023 Porcine growth hormone analogs
An analog of porcine growth hormone, is disclosed which retains the diabetogenic, insulin-sparing and lipolytic properties of porcine growth hormone while being capable of improving growt...
84 88102420 Assay for anti-pre-s antibody
An assay for anti-pre-S antibody in a serum specimen which comprises adding a carrier having Protein A bound thereto to a mixture containing the serum specimen and a pre-S peptide labeled...
85 88102311 Crystalline human proinsulin and process for its production
The present invention relates to crystalline human proinsulin and process for its production. The preparation comprises (a) preparing an aqueous mixture containing from about 5 to about 5...
86 88101579 Preparation of Earthworm thrombus enzyme and its appraisal method
Earthworm thrombolytic enzyme is a proteinase which is prepared from earthworm. The preparation includes: salting-out with ammonium sulfate, ultrafiltration, and purification by DEAE-cel...
87 94191690 35/31 KDA subunit of the entamoeba histolytica adherence lectin
The 35/31 kDa subunit of the Gal/GalNAc lectin and DNA encoding this protein in various strains of E. histolytica are provided. These materials are useful in vaccines and diagnostic assay...
88 94192136 Method of using insulin-like growth factor binding proteins
The invention relates to methods of using insulin-like growth factor binding proteins (
89 88103015 Cyclic anticoagulant peptides
This invention relates to cyclic peptide derivatives which are useful anticoagulant agents.
90 98118445 Cellulose binding domain
A cellulose binding domain (CBD) having a high affinity for crystalline cellulose and chitin is disclosed, along with methods for the molecular cloning and recombinant production thereof....
91 94191771 1,5 benzodiazepine derivatives having CCK and/or gastrin antagonistic activity
The present invention relates to compounds of general formula (I) and physiologically acceptable salts thereof wherein the group NR1R2 represents a 5-7 membered saturated heterocyclic rin...
92 94104101 Method for extracting albumen from animal's blood by precipitating method
The present invention relates to a method for extracting albumen from animal's blood by using precipitation method. Said ivnention uses animal blood serum (blood plasma), and adds 95% et...
93 94193193 A truncated keratinocyte growth factor (KGF) having increased biological activi...
The present invention relates to a keratinocyte growth factor fragment, KGFdes1-23, or an analog thereof that is composed of a portion of an amino acid sequence of mature, full length ker...
94 94191869 Immunoparticles bearing monoclonal anti-CD4 antibodies and utilisation thereof
The invention relates to immunonanoparticles comprised of nanoparticles of a polymer of a methyliden malonate compound coated with anti-CD4 antibodies, as well as their utilisation for pr...
95 94112129 Protein and polypeptide mercapto-polyglycol (PEG) reagent
The PEG reagent, N-maleimide amino n-caproic acid-mPEG ester, is used for modifying solubility, stability and immunogen nature of protein and polypeptide and also for preparing medical P...
96 94105201 After-treatment method for producing thuricide suspension
By means of the said post-treatment of Bacillus thuringiensis suspension, can be produced various suspension, slurry, powder, wettable powder, floating agent, etc. with different virulen...
97 94192528 Tricyclopolyazamacrocyclophosphonic acids, complexes and derivatives thereof, f...
The invention discloses the Tri- and tetra-cyclopolyazamacrocyclophosphonic acid compounds and their derivatives which may form inert complexes with Gd, Mn or Fe ions. The overall charge ...
98 94195058 Alpha-1-antichymotrypsin analogues having elastase inhibitory activity
The present invention provides an analogue of human alpha-1-antichymotrypsin where the amino acid at position 358 is selected from the group consisting of methionine, isoleucine, valine, ...
99 94105042 Artifical antigen preparation-hapten and protein cross-link method
The present invention relates to a new type artificial synthetizing method of antigen. Firstly the semiantigen (it mainly is phosphorous compound) is linked on L-lysine or polypeptide, a...
100 94105038 Vaccin peptide of blood fluke
the polypeptide as organic compound may be used to prepare the vaccine kind of medicines to resist schistosomiasis because of its protective immunity to such disease, and has the basic s...
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